Figure 1.

CXCR4 antagonism corrects the peripheral panleukopenia in Cxcr4^+/1013 mice. (A) Experimental design for CXCR4 signaling inhibition by CXCR4 antagonist X4-185 in WT and Cxcr4^+/1013 mice. Absolute (B) leucocyte, (C) lymphocyte, (D) granulocyte, and (E) monocyte counts were determined in the blood of WT and Cxcr4^+/1013 mice 3 hours after the last dose on day 7. Data (mean + SEM) were from two independent experiments with 6–10 mice per group. Statistics were calculated using the nonparametric Mann-Whitney test, two-sided. *p < 0.05, **p < 0.01, ***p < 0.0001. CXCR4, C-X-C chemokine receptor 4; d, day; SEM, standard error of the mean; Veh., vehicle; WT, wild-type.