Figure 3.

CXCR4 antagonism normalizes the splenic T-cell compartment in Cxcr4^+/1013 mice. Absolute (A) CD4⁺ T-cell counts, (B) CD8⁺ T-cell counts, and (C) CD4/CD8 T-cell ratio were determined in the blood 3 hours after the last dose on day 28. Total (D) CD4 T-cell numbers, (E) CD8 T-cell numbers, and (F) CD4/CD8 T-cell ratio were determined in the spleen of WT and Cxcr4^+/1013 mice after 28 days of X4-185 treatment. Data (mean + SEM) were from two independent experiments with 6–10 mice per group. Statistics were calculated using the nonparametric Mann-Whitney test, two-sided. *p < 0.05, **p < 0.01. CXCR4, C-X-C chemokine receptor 4; SEM, standard error of the mean; Veh., vehicle; WT, wild-type.