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. 2024 Nov 11;15:1468823. doi: 10.3389/fimmu.2024.1468823

Figure 4.

Figure 4

CXCR4 antagonism normalizes the splenic B-cell compartment in Cxcr4+/1013 mice. (A) Absolute B-cell counts were determined in the blood of WT and Cxcr4+/1013 mice 3 hours after the last dose on day 7. (B) Total splenic B-cell number in WT and Cxcr4+/1013 mice after 28 days of X4-185 treatment. The frequency of (C) FO or (D) MZ B cells and the total numbers of (E) FO or (F) MZ B cells were determined in the spleen of WT and Cxcr4+/1013 mice after 28 days of X4-185 treatment. Data (mean + SEM) were from two independent experiments with 6–10 mice per group. Statistics were calculated using the nonparametric Mann-Whitney test, two-sided. *p < 0.05, **p < 0.01, ***p < 0.001. CXCR4, C-X-C chemokine receptor 4; FO, follicular; MZ, marginal zone; SEM, standard error of the mean; Veh., vehicle; WT, wild-type.