Table 1.
Effects of CXCR4 antagonist X4-185 on blood cell counts in WT and Cxcr4+/1013 mice.
| Cell type | WT mice | Cxcr4+/1013 mice | ||
|---|---|---|---|---|
| Mean fold-increase | p-value | Mean fold-increase | p-value | |
| Leukocyte | 1.4 | 0.1270 | 5.5 | 0.0006 |
| Granulocyte | 3.1 | 0.0017 | 6.5 | 0.0006 |
| Mature Neutrophil | 2.7 | 0.0012 | 5.9 | 0.0002 |
| Monocyte | 2.0 | 0.0093 | 5.9 | 0.0006 |
| Lymphocyte | 1.2 | 0.3124 | 5.7 | 0.0006 |
| B cells | 1.5 | 0.1807 | 19.1 | 0.0006 |
| CD4-T cells | 1.2 | 0.8357 | 2.4 | 0.0262 |
| CD8-T cells | 2.0 | 0.5093 | 7.3 | 0.0041 |
Mean fold-increase and p-value were compared with vehicle-treated mice. CXCR4, C-X-C chemokine receptor 4; WT, wild-type.