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. 2024 Nov 11;18:1480000. doi: 10.3389/fnins.2024.1480000

Figure 2.

Figure 2

Diethyl butylmalonate improves depression in 5×FAD mice. (A) The frequency entries in open arms, (B) head entries in open arms times, (C) representative track plots of Con + Veh, Con + DBM, 5×FAD + Veh and 5×FAD + DBM groups recorded by SMART video tracking system in the elevated plus maze test. (D) Time in the central zone, (E) distance in the central zone, (F) entries in the central zone, (G) index of time in the central zone and (H) index of distance in the central zone were recorded in the open field test. (I) Representative track plots of Con + Veh, Con + DBM, 5×FAD + Veh and 5×FAD + DBM groups recorded by SMART video tracking system in the open field test. (J) Time immobile was recorded in tail suspension test. (K) Time immobile in forced swimming test. n = 12 mice for each group. Values are mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001.