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. 2024 Nov 24;30(11):e70129. doi: 10.1111/cns.70129

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© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cell type enrichment of PLS+ genes and correlation between regional GABA receptor expression and case–control t‐value. (A) Excitatory and inhibitory neurons were significantly enriched in FBTCS− patients. (B) Only excitatory neurons were significantly enriched in in FBTCS+ patients. (C) The scatter plot shows the regional GABA receptor expression was significantly correlated with case–control t‐value of FBTCS−, with each dot representing a brain region. (D) No significant correlation was found between GABA receptor expression and case–control t‐value of FBTCS+. FBTCS−, without focal to bilateral tonic–clonic seizures; FBTCS+, with focal to bilateral tonic–clonic seizures.