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. 2024 Nov 25;14(50):37554–37569. doi: 10.1039/d4ra07173e

In vitro anticancer activity of the products 2a–j against TK-10 and A549 cancer cells.

Compounds IC50 (μg mL−1)
TK-10 A549
2a ≥100 ≥100
2b ≥100 66.9 ± 0.7
2c 11.7 ± 2.3 33.4 ± 0.8
2d ≥100 ≥100
2e 1.0 ± 0.1 2.4 ± 0.3
2f ≥100 ≥100
2g 5.1 ± 0.7 10.9 ± 1.2
2h 2.3 ± 0.1 4.7 ± 0.2
2i ≥100 44.7 ± 3.6
2j 1.4 ± 0.1 1.0 ± 0.1
Doxorubicin 1.4 ± 0.4 1.9 ± 0.7