Figure 3.

Short-term effects of PS-IONPs on the iron distribution in the organs of mice with a persistent inflammatory state in comparison to the control groups (0.25 months after intravenous application). Experimental group: “+/+”—animals with a persistent inflammatory state (zymosan: 7 cycles of 18 µg/kg body weight, PS-IONPs: 50 µmol Fe/kg body weight). Control groups: “−/−”—animals without persistent inflammation and no intravenous PS-IONP injection, and “−/+”—animals without persistent inflammation but with intravenous injection of PS-IONPs. Data are represented as iron content in milligrams per gram of dry tissue mass (individual data points), along with the mean and standard deviation; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 (t-test with Welch’s correction).