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a) Change from baseline to week 52 in pre-bronchodilator FEV1 and b) AAER over 52 weeks in patients with and without PAO at baseline. n indicates the number of patients who contributed to the analysis. AAER: annualised asthma exacerbation rate; FEV1: forced expiratory volume in 1 s; LS: least-squares; PAO: persistent airflow obstruction; Q4W: every 4 weeks.
