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. Author manuscript; available in PMC: 2024 Nov 25.
Published in final edited form as: Neuron. 1999 Sep;24(1):253–260. doi: 10.1016/s0896-6273(00)80837-5

Figure 2.

Figure 2.

Mechanical and Thermal Nociception and Response to Acetic Acid in PKCϵ Mutant Mice

(A) Mechanical thresholds were measured in eight wild-type (black bars) and eight mutant (gray bars) mice in response to VFH (4 g) stimulation. Responses were measured before (basal) and after intraplantar injection of 100 ng epinephrine (Epi) or PGE2. Asterisk, p < 0.001 (ANOVA and Scheffe F test).

(B) Thermal nociceptive thresholds in eight wild-type (black bars) and eight mutant (gray bars) mice before and after intraplantar injection of 100 ng epinephrine (Epi) or PGE2. Asterisk, p < 0.001 (ANOVA and Scheffe F test).

(C) Writhing response to acetic acid administration in four wild-type (+/+) and four mutant (−/−) mice. Asterisk, p < 0.05 (Student’s unpaired t test).