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. 2024 Nov 25;23:264. doi: 10.1186/s12943-024-02173-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Comparison of clinicopathological parameters and mutations among cohorts. A Clinicopathological characteristics of the Swedish locoregional (n = 719; 1 patient with missing survival information), Swedish metastatic (n = 228; 128 patients with metachronous metastases overlap with the locoregional cohort), and MSK (all patients, n = 934) cohorts. B Kaplan–Meier plots of overall survival in each cohort. C-D Bar plots of the frequency of single (C) and co-occurring (D) gene mutations in each cohort. Fisher exact analyses were performed between the cohorts and statistically significant differences are indicated by asterisks (***p < 0.001, **p < 0.01, and *p < 0.05)