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. 2024 Nov 25;19:88. doi: 10.1186/s13024-024-00779-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Genetic dissection of the CTSB locus in Parkinson’s disease risk. Locus zoom plots depicting the CTSB locus (± 500 kb) in Parkinson's disease GWAS with brain eQTLs. The top PD-associated variant (rs1293298) is highlighted in purple, and variants in strong LD (r² > 0.8) are in red. Each panel includes three plots: The left plot in each panel compares the p values from the PD GWAS and expression data for each variant. Variants that are in the top right corner of this plot are therefore associated with both risk of PD and CTSB expression. The top right plots depict the PD GWAS association in this locus and is identical in all four panels. On the bottom right of each panel, the plot depicts the association between variants in this locus and CTSB RNA expression in the relevant tissue. A PD GWAS plotted together with Basal ganglia (Caudate) eQTL. B PD GWAS plotted together with Cortex eQTL. C PD GWAS plotted together with Nucleus accumbens eQTL. D PD GWAS plotted together with Basal ganglia (Putamen) eQTL