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. 2024 Nov 25;19:88. doi: 10.1186/s13024-024-00779-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Cathepsin B inhibitors potentiate the effect of α-syn PFFs on dopaminergic neurons: A) CatB activity measured by fluorogenic assay in DA neurons treated with 1 μM CA074me. B Representative immunofluorescent images from high-content confocal imaging of DA neurons treated with CA074me (1 μM) and/or α-syn PFFs (300 nM) and stained for Map2 and pSyn-S129. C Quantification of pSyn-S129 in Map2-positive cells 3-weeks after PFF and/or CA074me treatment in either Control (AIW002-2) DA neurons or isogenic neurons lacking endogenous α-syn (AIW002-2 SNCA-KO). D Quantification of pSyn-S129 in control DA neurons 2, 3, or 4 weeks after PFF (300 nM) and/or CA074me treatment. Bonferroni-corrected t-tests, ** p < 0.01, *** p < 0.001, **** p < 0.0001