Fig. 2.

Local genetic correlations, and genetic overlap of the polycystic ovary syndrome and breast cancer. (a)Volcano plots of LAVA local genetic correlation coefficients (rho, y-axis) against -log₁₀ (p-values) for each pairwise analysis per locus. Larger dots with black circles represent significantly correlated loci after the Bonferroni correction. Note that the Volcano plots were plotted at p-values truncated by 1.00E-04 for better visualisation. (b) MiXeR Venn diagrams show the number of shared and disorder-specific ‘causal’ variants in thousands for each pair of disorders