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. 2024 Nov 25;26:161. doi: 10.1186/s13058-024-01923-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — The Overall Landscape of the Pleiotropic Associations Across polycystic ovary syndrome and breast cancer. A circular dendrogram included polycystic ovary syndrome(PCOS) at the centre point and three types of breast cancer(including breast cancer all[BCALL], estrogen receptor-positive breast cancer[ERPBC], estrogen receptor-negative breast cancer[ERNBC]) in the inner circle, resulting in 3 trait pairs. A total of 11 pleiotropic loci were identified across 3 trait pairs (second circle). A total of 13 significant pleiotropic genes were further identified by MAGMA and the genes with the tissue specificity identified by E-MAGMA were also highlighted (red font annotation)