Table 2.
Aqueous humour levels of complement proteins/factors in RVO patients and controls
| Subgroups of RVO | |||||
|---|---|---|---|---|---|
| Variables median (Q1;Q3) |
Control | RVOa | CRVOc | BRVOc | P-values |
| (n = 13) | (n = 19) | (n = 5) | (n = 14) | BRVO vs. CRVOb | |
| C1q(ng/mL) | 2.04 (1.34;4.34) | 12.34 (5.62;19.70)** | 16.47 (16.26;20.75)** | 8.59 (4.77;14.61)** | 0.034 |
| C2(ng/mL) | 3.68 (3.02;5.28) | 34.75 (23.46;77.60)** | 61.01 (34.75;77.60)** | 33.64 (22.36;73.73)** | 0.343 |
| C4(ng/mL) | 458.48 (280.26;589.80) | 980.32 (788.49;1131.00)** | 1128.00 (1060.58;1150.00)** | 868.24 (730.76;1013.00)** | 0.026 |
| C4b(ng/mL) | 70.27 (50.92;93.11) | 124.68 (103.84;131.25)** | 124.68 (119.05;131.25)** | 124.35 (73.27;101.16)* | 0.500 |
| C3(ng/mL) | 154.76 (116.00;173.74) | 180.92 (138.76;179.94) | 138.76 (104.92;185.34) | 185.81 (99.30;131.94) | 0.298 |
| C3b/iC3b(ng/mL) | 15.83 (10.25;20.28) | 187.54 (122.34;410.28)** | 472.58 (135.62;508.07)** | 175.74 (152.34;219.15)** | 0.257 |
| C5(ng/mL) | 2.25 (0.68;2.48) | 11.46 (5.14;29.59)* | 32.54 (29.59;41.40)** | 7.48 (1.82;13.06) | 0.005 |
| C5a(pg/mL) | 1.14 (1.14;2.56) | 11.46 (5.14;29.59)** | 60.90 (50.84;107.78)** | 7.48 (1.82;13.06)* | 0.156 |
| CFB(ng/mL) | 186.34 (110.55;276.14) | 380.21 (257.06;531.40)** | 380.21 (364.31;603.14)** | 352.79 (207.64;494.82)* | 0.257 |
| CFD(ng/mL) | 48.47 (42.90;55.59) | 64.20 (52.67;71.44) | 71.44 (65.68;88.50)* | 58.04 (51.71;67.38) | 0.070 |
| CFI(ng/mL) | 34.77 (27.35;88.94) | 84.12 (59.69;185.17) | 229.89 (165.75;259.30)** | 66.47 (44.75;91.31) | 0.005 |
| CFH(ng/mL) | 71.26 (51.77;76.57) | 320.76 (218.34;572.41)** | 665.26 (325.59;674.02)** | 267.73 (216.35;352.33)** | 0.044 |
| MBL(ng/mL) | 0.16(0.11;0.21) | 0.68(0.28;1.00)** | 1.09(1.00;1.02)** | 0.45(0.28;0.71)** | 0.005 |
* p < 0.05; ** p < 0.01. Bold indicating p value was statistically significant
a, Covariance analysis of complement proteins/factors between controls and RVO patients after adjusting for age; b, Mann–Whitney U test analysis between BRVO and CRVO patients; c, Covariance analysis of complement proteins/factors between controls and CRVO, BRVO patients after adjusting for age
RVO: retinal vein occlusion; BRVO: branch retinal vein occlusion; CRVO: central retinal vein occlusion; CFB: complement factor B; CFD: complement factor D; CFI: complement factor I; CFH: complement factor H; MBL: mannose-binding lectin