Table 3.
Plasma levels of complement proteins/factors in RVO patients and controls
| Subgroups of RVO | |||||
|---|---|---|---|---|---|
| Variables median (Q1;Q3) |
Control | RVOa | CRVOc | BRVOc | P-values |
| (n = 20, ×103ng/mL) | (n = 20, ×103ng/mL) | (n = 6, ×103ng/mL) | (n = 14, ×103ng/mL) | BRVO vs. CRVOb | |
| C1q | 29.55 (28.03;36.45) | 34.41 (28.39;40.75) | 35.32 (28.44;40.31) | 34.41 (28.34;42.28) | 0.779 |
| C2 | 0.98 (0.85;2.23) | 7.48 (1.75;40.13) | 3.27 (1.55;10.28) | 8.95 (1.95;15.25)* | 0.547 |
| C4 | 507.73 (430.96;576.00) | 654.14 (592.35;1459.17)** | 622.29 (563.67;729.56) | 681.05 (592.65;788.78)** | 0.494 |
| C4b | 20.91 (17.38;25.60) | 27.78 (59.24;75.09)* | 25.90 (20.27;28.34) | 28.20 (25.04;33.35)* | 0.239 |
| C3 | 46.32 (34.73;52.77) | 28.26 (21.83;30.36) | 42.57 (21.70;63.54) | 28.26 (21.97;68.52) | 0.904 |
| C3b/iC3b | 40.75 (31.11;50.24) | 106.66 (72.86;161.01)** | 109.93 (59.10;184.98)** | 106.66 (81.80;127.99)** | 0.904 |
| C5 | 10.81 (0.92;12.40) | 11.53 (10.16;13.77) | 13.25 (10.25;13.84) | 10.83 (10.07;13.71) | 0.547 |
| CFB | 15.81 (14.18;17.98) | 182.12 (161.52;220.99)* | 196.29 (164.12;226.83) | 175.81 (158.92;215.16) | 0.718 |
| CFD | 6.23 (5.41;7.07) | 5.84 (4.85;7.11) | 5.64 (5.04;5.92) | 6.29 (4.81;7.58) | 0.494 |
| CFI | 22.89 (9.87;26.80) | 26.19 (22.45;33.04) | 34.31 (26.98;37.38)* | 23.12 (10.70;28.36) | 0.015 |
| CFH | 204.98 (191.73;232.19) | 226.95 (206.79;247.66)* | 231.90 (223.37;253.39) | 215.19 (199.54;241.93) | 0.444 |
| MBL | 2.05 (1.04;4.77) | 3.45 (1.20;6.09) | 4.10 (1.53;5.39) | 3.45 (1.18;6.78) | 0.968 |
* p < 0.05; ** p < 0.01. Bold indicating p value was statistically significant
a, Covariance analysis of complement proteins/factors between controls and RVO patients after adjusting for age; b, Mann–Whitney U test analysis between BRVO and CRVO patients; c, Covariance analysis of complement proteins/factors between controls and CRVO, BRVO patients after adjusting for age
RVO: retinal vein occlusion; BRVO: branch retinal vein occlusion; CRVO: central retinal vein occlusion; CFB: complement factor B; CFD: complement factor D; CFI: complement factor I; CFH: complement factor H; MBL: mannose-binding lectin