Table 4.
Correlation between aqueous humour complement proteins/factors and visual acuity and OCTA parameters in RVO patients
| C1q | C2 | C4 | C4b | C3 | C3b/iC3b | C5 | C5a | CFB | CFD | CFI | CFH | MBL | VA | FAZ | PERIM | CRT | ILM-IPL | SVD | DVD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C1q | / | 0.656** | 0.805** | 0.542* | 0.137 | 0.656** | 0.731** | 0.533* | 0.570* | 0.407 | 0.626** | 0.782** | 0.638** | 0.282 | -0.251 | -0.067 | 0.135 | 0.188 | 0.088 | -0.218 |
| C2 | 0.002 | / | 0.672** | 0.328 | 0.554* | 0.489* | 0.824** | 0.789** | 0.825** | 0.453 | 0.333 | 0.853** | 0.637** | 0.004 | -0.547* | -0.349 | 0.042 | 0.079 | 0.278 | -0.254 |
| C4 | 0.000 | 0.002 | / | 0.665** | 0.181 | 0.474* | 0.801** | 0.644** | 0.568* | 0.447 | 0.540* | 0.851** | 0.496* | 0.240 | -0.063 | 0.212 | 0.127 | 0.276 | 0.040 | -0.181 |
| C4b | 0.016 | 0.170 | 0.002 | / | -0.096 | 0.456* | 0.319 | 0.179 | 0.056 | 0.505* | 0.507* | 0.484* | 0.263 | 0.160 | 0.121 | 0.486* | 0.187 | 0.393 | 0.152 | -0.032 |
| C3 | 0.576 | 0.014 | 0.459 | 0.694 | / | -0.091 | 0.318 | 0.502* | 0.556* | 0.146 | -0.098 | 0.346 | 0.201 | -0.347 | -0.528* | -0.404 | -0.126 | -0.313 | 0.143 | -0.439 |
| C3b/iC3b | 0.002 | 0.033 | 0.040 | 0.050 | 0.710 | / | 0.482* | 0.340 | 0.235 | 0.116 | 0.279 | 0.563* | 0.428 | 0.401 | -0.198 | -0.168 | -0.180 | 0.100 | 0.124 | 0.121 |
| C5 | 0.000 | 0.000 | 0.000 | 0.183 | 0.184 | 0.037 | / | 0.877** | 0.769** | 0.499* | 0.426 | 0.919** | 0.722** | 0.209 | -0.472* | -0.167 | 0.053 | 0.195 | -0.015 | -0.120 |
| C5a | 0.019 | 0.000 | 0.003 | 0.464 | 0.029 | 0.154 | 0.000 | / | 0.632** | 0.407 | 0.144 | 0.795** | 0.611** | 0.133 | -0.442 | -0.146 | -0.008 | 0.257 | 0.126 | -0.098 |
| CFB | 0.011 | 0.000 | 0.011 | 0.819 | 0.013 | 0.333 | 0.000 | 0.004 | / | 0.275 | 0.251 | 0.709** | 0.493* | 0.068 | -0.561* | -0.389 | -0.086 | -0.24 | 0.069 | -0.377 |
| CFD | 0.084 | 0.052 | 0.055 | 0.027 | 0.552 | 0.637 | 0.030 | 0.084 | 0.254 | / | 0.477* | 0.535* | 0.673** | 0.059 | -0.242 | 0.137 | 0.484* | 0.468* | 0.350 | 0.041 |
| CFI | 0.004 | 0.163 | 0.017 | 0.027 | 0.689 | 0.247 | 0.069 | 0.557 | 0.300 | 0.039 | / | 0.461* | 0.706** | 0.000 | -0.202 | -0.053 | 0.617** | 0.355 | -0.241 | -0.230 |
| CFH | 0.000 | 0.000 | 0.000 | 0.036 | 0.147 | 0.012 | 0.000 | 0.000 | 0.001 | 0.018 | 0.047 | / | 0.699** | 0.204 | -0.430 | -0.181 | 0.154 | 0.158 | 0.121 | -0.190 |
| MBL | 0.003 | 0.003 | 0.031 | 0.276 | 0.409 | 0.067 | 0.000 | 0.005 | 0.032 | 0.002 | 0.001 | 0.001 | / | 0.107 | − 0.571* | -0.327 | 0.471* | 0.386 | 0.073 | -0.056 |
| VA | 0.242 | 0.989 | 0.323 | 0.512 | 0.146 | 0.089 | 0.391 | 0.588 | 0.782 | 0.809 | 1.000 | 0.401 | 0.664 | / | 0.030 | 0.121 | -0.006 | -0.021 | -0.003 | 0.108 |
| FAZ | 0.300 | 0.015 | 0.797 | 0.622 | 0.020 | 0.416 | 0.041 | 0.058 | 0.012 | 0.318 | 0.408 | 0.066 | 0.011 | 0.899 | / | 0.728** | 0.019 | 0.084 | 0.133 | 0.286 |
| PERIM | 0.786 | 0.143 | 0.383 | 0.035 | 0.087 | 0.491 | 0.494 | 0.552 | 0.099 | 0.576 | 0.831 | 0.459 | 0.171 | 0.612 | 0.000 | / | 0.029 | 0.326 | 0.204 | 0.170 |
| CRT | 0.581 | 0.864 | 0.604 | 0.444 | 0.606 | 0.461 | 0.830 | 0.974 | 0.726 | 0.036 | 0.005 | 0.528 | 0.042 | 0.978 | 0.937 | 0.902 | / | 0.462* | 0.134 | -0.167 |
| ILM-IPL | 0.441 | 0.748 | 0.252 | 0.096 | 0.192 | 0.684 | 0.423 | 0.288 | 0.321 | 0.043 | 0.136 | 0.518 | 0.102 | 0.932 | 0.726 | 0.161 | 0.040 | / | 0.235 | 0.287 |
| SVD | 0.720 | 0.249 | 0.869 | 0.534 | 0.560 | 0.613 | 0.951 | 0.608 | 0.780 | 0.141 | 0.320 | 0.623 | 0.766 | 0.991 | 0.577 | 0.389 | 0.574 | 0.318 | / | 0.195 |
| DVD | 0.371 | 0.295 | 0.459 | 0.898 | 0.060 | 0.621 | 0.626 | 0.689 | 0.111 | 0.867 | 0.344 | 0.437 | 0.821 | 0.651 | 0.222 | 0.474 | 0.481 | 0.221 | 0.409 | / |
*P ≤ 0.05, **p ≤ 0.01; The value above the diagonal empty cell (/) represents the Spearman correlation coefficient. The value below the diagonal empty cell (/) indicates the level of statistical significance of the correlation. CFB: complement factor B; CFD: complement factor D; CFI: complement factor I; CFH: complement factor H; MBL: mannose-binding lectin; VA: visual acuity; FAZ: foveal avascular zone; PERIM: perimeter of foveal avascular zone; CRT: central retinal thickness; ILM-IPL: inner limiting membrane-inner plexiform layer; SVD: superficial capillary plexus vessel density; DVD: deep capillary plexus vessel density; RVO: retinal vein occlusion