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. Author manuscript; available in PMC: 2024 Nov 25.
Published in final edited form as: Nat Biomed Eng. 2023 Nov 30;8(4):380–396. doi: 10.1038/s41551-023-01143-w

Extended Data Figure 7: Zip2R augments the antitumor activity of EphA2-CAR in the A673 model.

Extended Data Figure 7:

(a) Experimental scheme of s.c. A673 model; mice received a single i.v. dose of 1×106 CAR T cells on day 7 post tumor cell injection. (b) Tumor volume of mice treated with indicated constructs (N=4; donor 1). (c) Kaplan-Meier survival curve (*p<0.05, log-rank test). (d) Tumor volume of mice treated with indicated constructs (N=5; donor 2). (e) Tumor volume following rechallenge (dashed line) with A673 WT cells on the contralateral flank (N=4-5; tumor rejection: CAR: 0/5; CAR.Zip2R: 2/4). (f) Kaplan Meier survival following rechallenge.