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. Author manuscript; available in PMC: 2024 Nov 25.
Published in final edited form as: Nat Biomed Eng. 2023 Nov 30;8(4):380–396. doi: 10.1038/s41551-023-01143-w

Figure 2: Zip2R and Zip7R activate distinct signaling pathways as judged by multiplexed phosphoproteomics.

Figure 2:

(a) Samples and experimental workflow of phosphoproteomic analysis. (b) Hierarchical clustering of top 700 differentially expressed proteins (p<0.05). (c) IKAP prediction of kinase activity in CD4+ (left) and CD8+ (right) cells. (d) Top upregulated proteins compared to NT cells in CD4+ (top) and CD8+ (bottom) cells. (e) Differentially expressed proteins in Zip7R versus Zip2R transduced CD4+ (top) and CD8+ (bottom) cells