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. Author manuscript; available in PMC: 2024 Nov 25.
Published in final edited form as: Nat Biomed Eng. 2023 Nov 30;8(4):380–396. doi: 10.1038/s41551-023-01143-w

Figure 6: CAR.ZipR T cells sustain effector function through memory/survival or hybrid memory/effector transcriptional programs.

Figure 6:

(a) scRNAseq experimental scheme. (b) Number of cells analyzed in each sample. (c) UMAP projection of unstimulated or stimulated CAR or CAR.ZipR T cell populations from two donors. (d) GSEA of unstimulated or stimulated CD8+ CAR.ZipR T cell populations in comparison to CAR T cells. (e) Expression of memory, effector/cytotoxicity, inhibition/exhaustion, and activation markers in unstimulated or stimulated CD8+ CAR and CAR.ZipR T cell populations. (f) Expression of selected genes in unstimulated or stimulated CD8+ CAR and CAR.ZipR T cell populations (Wilcoxon rank sum test with Bonferroni correction; ****adjusted p value < 0.0001 and log2FC > 0.5 or < −0.5).