TABLE 1.

Overview of the Included Samples, Demographic and Epidemiologic Characteristics of the Patients (Age, Sex, Morbidity) as well as Radiotherapy (RT) Regimen Analyses and Recorded Radiotoxicity Grades According to RTOG/EORTC Late Radiation Morbidity Criteria: Acute (Grade 1–2) and Late (Grade 1–3) Toxicity as well as Late Toxicity Location

Patient ID	Age (years)	Sex	Morbidity		Partial body Irradiation (25 fractions over 5 weeks)		Equivalent absorbed body dose		Recorded acute and late toxicity			Sampling time points (# RT fraction)
			Tumor localization	Tumor grade	Dose per fraction	Prescribed total dose (Gy)	Irradiated blood volume (dm3)	Absorbed blood dose per fraction (Gy)	Acute toxicity (Grade)	Late toxicity (Grade)	Late toxicity location	0	1	2	25
P1	50	male	Submandibular gland	3	2	50	1	0.11	1	early death	none	x	x	x	x
P2	60	male	Skin	3	2	60	1	0.09	1	early death	none	x	x	x	x
P3	70	male	Tonsil	2	2.1	70	0.4	0.07	2	2	s.c./mucosal	x	x	x	x
P4	50	male	Base of tongue	2	2.1	50	0.5	0.11	2	3	s.c./mucosal	x	x	x
P5	50	male	Supraglottis	3	2.1	50	0.7	0.09	2	2	s.c./mucosal	x	x	x
P6	66	male	Hypopharynx	2	2	66	0.5	0.08	1	1	s.c./mucosal	x	x	x
P7	66	male	Larynx	3	2	66	0.5	0.09	1	1	s.c./mucosal	x	x	x
P8	60	male	Disseminated neoplasm	2	2	60	0.4	0.08	1	1	s.c./mucosal	x	x	x

Notes. Further, the sampling time points are depicted for each patient according to radiotherapy fractions (RT1 = 24 h after the start of Radiotherapy, RT1 ≈ 48 h after the start of radiotherapy, RT25 ≈ 5 weeks after the start of radiothearpy). m – male, s.c. - subcutaneous.