TABLE 2.
Overview of the GE Results (Normalized Ct Values) and the Significant Correlations with Acute (Grade 1–2) and Late Toxicity Grade (Categories of Grade 1–2 and 3–4)
| Normalized Ct value | ||||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| n | mean | stdev | min | max | FC | p-value | ||
| Acute toxicity - grade | ||||||||
| CCNG1 | ||||||||
| RT 1st&2nd fraction combined | grade 1 | 8 | 10.5 | 0.8 | 9.3 | 11.7 | Ref | |
| grade 2 | 6 | 11.4 | 0.5 | 10.8 | 12.4 | 0.54 | 0.04 | |
| DDB2 | ||||||||
| RT 1st&2nd fraction combined | grade 1 | 8 | 10 | 1.3 | 7.7 | 11.7 | Ref | |
| grade 2 | 6 | 11.2 | 0.6 | 10.5 | 12.2 | 0.44 | 0.06 | |
| Late toxicity - grade | ||||||||
| HPRT1 | ||||||||
| RT 1st&2nd fraction combined | grade 1–2 | 8 | 12.2 | 0.5 | 11.4 | 13.2 | Ref | |
| grade 3–4 | 6 | 13.2 | 0.7 | 12.5 | 14 | 0.50 | 0.006 | |
| POU2AF1 | ||||||||
| RT 1st&2nd fraction combined | grade 1–2 | 7 | 12.7 | 1.7 | 10.1 | 15.4 | Ref | |
| grade 3–4 | 5 | 15.5 | 1.1 | 14.2 | 17.2 | 0.14 | 0.02 | |
| WNT3 | ||||||||
| pre-exposure | grade 1–2 | 3 | 14.7 | 1.1 | 13.6 | 16.2 | Ref | |
| grade 3–4 | 3 | 17.8 | 0.9 | 16.6 | 18.8 | 0.12 | 0.04 | |
Notes. Fold changes were calculated with grade 1 in acute toxicity and grade 1–2 in late toxicity as the reference. Provided are numbers (n) per category and corresponding descriptive statistics: mean, standard deviation (stdev), minimum (min) and maximum (max), fold changes difference (FC) with corresponding reference. Only genes that showed significant or borderline significant results are depicted. Data for all genes is shown in Supplemental Table S2 (https://doi.org/10.1667/RADE-23-00176.1.S3).