TABLE 3.
Overview of the Simple Direction of Response (Up- or Downregulation, FC > |1.2|) or Non-Response for PHPT1, CCNG1, CDKN1A, GADD45, and SESN1 in Blood and Saliva Samples for each Patient over Three Time Points after the Start of Radiotherapy (RT) (RT1, RT2, RT25)
| Gene | Patient | Direction of FC | Overall conformity Saliva - Blood | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RT 1 | RT 2 | RT 25 | |||||||||||||||||
| Saliva | Blood | Saliva | Blood | Saliva | Blood | 1st + 2nd RT | all RT fractions | ||||||||||||
| up | down | up | down | up | down | up | down | up | down | up | down | yes (%) | no (%) | undefinded (%) | yes (%) | no (%) | undefinded (%) | ||
| CDKN1A | N2 | X | X | X | X | o | x | ||||||||||||
| N3 | x | o | X | X | X | X | |||||||||||||
| N4 | O | O | X | X | X | X | |||||||||||||
| N5 | x | x | X | X | x | ||||||||||||||
| N7 | X | X | X | X | |||||||||||||||
| N8 | x | o | O | O | 11/14 | 1/14 | 2/14 | 13/17 | 1/17 | 3/17 | |||||||||
| N9 | X | X | X | X | 78.6 | 7.1 | 14.3 | 76.5 | 5.9 | 17.6 | |||||||||
| PHPT1 | N2 | x | o | O | O | x | o | ||||||||||||
| N3 | x | o | X | X | O | O | |||||||||||||
| N4 | O | O | x | x | x | x | |||||||||||||
| N5 | x | o | o | x | x | ||||||||||||||
| N7 | x | x | o | x | |||||||||||||||
| N8 | O | O | X | X | 7/14 | 2/14 | 5/14 | 8/17 | 3/17 | 6/17 | |||||||||
| N9 | X | X | X | X | 50.0 | 14.3 | 35.7 | 47.1 | 17.6 | 35.3 | |||||||||
| CCNG1 | N2 | x | o | x | o | X | X | ||||||||||||
| N3 | x | o | X | X | x | o | |||||||||||||
| N4 | o | x | x | x | x | x | |||||||||||||
| N5 | x | x | x | x | x | ||||||||||||||
| N7 | X | X | X | X | |||||||||||||||
| N8 | x | o | x | o | 5/14 | 3/14 | 6/14 | 6/17 | 4/17 | 7/17 | |||||||||
| N9 | X | X | X | X | 35.7 | 21.4 | 42.9 | 35.3 | 23.5 | 41.2 | |||||||||
| GADD45A | N2 | X | X | x | x | x | o | ||||||||||||
| N3 | x | o | x | o | x | o | |||||||||||||
| N4 | o | x | x | o | x | x | |||||||||||||
| N5 | x | x | X | X | x | ||||||||||||||
| N7 | o | x | X | X | |||||||||||||||
| N8 | x | o | x | o | 5/14 | 2/14 | 7/14 | 5/17 | 3/17 | 9/17 | |||||||||
| N9 | X | X | X | X | 35.7 | 14.3 | 50.0 | 29.4 | 17.6 | 52.9 | |||||||||
| SESN1 | N2 | x | x | o | x | o | x | ||||||||||||
| N3 | o | o | x | o | o | x | |||||||||||||
| N4 | x | o | x | o | x | o | |||||||||||||
| N5 | x | o | x | o | x | ||||||||||||||
| N7 | x | x | o | o | |||||||||||||||
| N8 | x | o | x | o | |||||||||||||||
| N9 | o | o | x | x | 4/14 | 2/14 | 8/14 | 4/17 | 2/17 | 11/17 | |||||||||
| 28.6 | 14.3 | 57.1 | 23.5 | 11.8 | 64.7 | ||||||||||||||
Notes. FC ≥ |1.2| was considered as an up- or down-regulation represented by the symbol “x”, FC ≤ |1.2| was considered as an no de-regulation represented by the symbol “o”. The column “overall conformity Saliva - blood” provides a summary per gene for early radiotherapy fractions (RT1, RT2) and for all radiotherapy cycles (RT1, RT2, RT25). Conformity or no conformity in deregulation or undefined response between corresponding blood and saliva samples from the same patient at the same time point is depicted.