The combination DN + OA directly targeted STAT3 in A549 cells to decrease cell growth. Several proteins (STAT3, p-STAT3, cyclin-D1, Bcl-2, Bax) were measured using Western blotting analysis. The densitometric assessment performed earlier indicated that proteins were assessed using the Image Studio software. The replication of the housekeeping gene, β-actin, verified the equal loading of proteins. The mean value as well as the standard deviation of three separate experiments were assessed. The mean value ± SD is shown, *P < 0.05, **P < 0.001.