Table 1.
List of antisickling compounds with lowest inhibitory concentrations (LIC) less than 10 μM
| Name of Compound | IC50 (μM)* | LIC (μM)† |
|---|---|---|
| Ammonium Trichlorotellurate‡,§ | 0.032 ± 0.015 | 0.031 |
| Niferidil‡,** | 10.5 | 0.031 |
| Mavatrep | 0.23 ± 0.14 | 0.123 |
| Manoalide‡ | 0.33 ± 0.09 | 0.278 |
| HR325‡ | 3.0 ± 0.86 | 0.278 |
| NSD-721‡ | 13 ± 2.0 | 0.278 |
| FT-11‡ | 1.3 ± 1.0 | 0.278 |
| Mitapivat‡ | 0.25 ± 0.16 | 0.278 |
| ARA DMAP‡ | 3.9 ± 1.1 | 1.1 |
| Pafuramidine‡ | 6.0 ± 5.8 | 1.1 |
| Cisplatin‡,§,¶ | 1.3 ± 0.2 | 1.1 |
| Cloturin‡,‖ | 9.7 ± 0.5 | 1.1 |
| EF-4040‡ | 1.7 ± 0.4 | 1.1 |
| Cyclovalone‡ | 1.7 ± 0.7 | 1.1 |
| VML 530 | 1.5 ± 0.2 | 1.1 |
| Peruvoside‡ | NA# | 1.1 |
| ONO-7746 | 3.8 ± 2.0 | 1.1 |
| BMS-919373§,¶,‖ | 6.4 ± 8.1 | 1.1 |
| KUX-1151‡ | 5.3 ± 5.1 | 1.1 |
| NT-113 | 3.6 ± 2.8 | 1.1 |
| Curcumin | 0.50 ± 0.14 | 1.1 |
| AEG-33783‡,§ | 1.4 ± 0.5 | 1.1 |
| VRT-532‡ | 5.8 ± 0.7 | 2.5 |
| Licochalcone A | 4.3 ± 2.4 | 2.5 |
| NSC-150117 | 2.6 ± 0.7 | 2.5 |
| AT-101§ | 2.4 ± 0.1 | 2.5 |
| Darapladib§,¶ | 2.0 ± 0.4 | 2.5 |
| Oxyfedrine Hydrochloride | 2.9 ± 1.1 | 2.5 |
| Octenidine‡,§,¶ | NA# | 2.5 |
| WP-1066‡ | 3.9 ± 1.2 | 2.5 |
| Butein | 10 ± 3 | 2.5 |
| Ethacrynic Acid‡ | 3.3 ± 0.9 | 2.5 |
| TS-80‡ | 3.1 ± 1.6 | 2.5 |
| SC-1 | 10 ± 5 | 2.5 |
| Tucaresol | 3.1 ± 0.3 | 2.5 |
| CBS-1114 | 7.2 ± 5.2 | 2.5 |
| YM 57158 | 2.5 ± 0.3 | 2.5 |
| Allisartan‡ | 7.8 ± 4.6 | 2.5 |
| Elisartan Potassium | 5.6 ± 4.0 | 2.5 |
| Samixogrel | 4.2 ± 2.0 | 2.5 |
| AM-103‡,§,‖ | 4.5 ± 2.6 | 2.5 |
| ODM-103‡,‖ | 9.0 ± 2.2 | 2.5 |
| ON-09310 | 5.9 ± 1.7 | 2.5 |
| P-7435‡ | NA# | 2.5 |
| AZD-4769 | 2.5 ± 0.9 | 2.5 |
| Calcimycin | 2.1 ± 0.1 | 2.5 |
| Vadadustat‡ | 7.9 ± 6.3 | 2.5 |
| Metabromsalan‡ | 8.0 ± 2.5 | 2.5 |
| IMD-0560 | 2.3 ± 1.1 | 2.5 |
| laflunimus | 7.2 ± 3.7 | 2.5 |
*Concentration that produces 50% inhibition.
†Lowest concentration of statistically significant inhibition.
‡LIC is antisickling for cells from 2 of 3 donors.
§Compound causes lysis at high concentration, antisickling at lower concentration.
¶IC50s could only be determined for one of the donor samples for these compounds because of an insufficient number of data points higher than 0% inhibition.
#Incubated for 8 h.
‖IC50s could not be determined for these three compounds because of an insufficient number of data points higher than 0% inhibition.
**IC50s could only be determined for 2 of the 3 donor samples for these compounds because of an insufficient number of data points higher than 0% inhibition.