Compilation of ongoing research on thiophene derivatives for the development of antidiabetic agents.

Compound code	Indication	Biological target	Mechanism	Status	Mode of drug discovery	Ref.
1	Antidiabetic agent	Peroxisome proliferator-activated receptor γ (PPAR γ)	Inhibits PPAR γ, which plays a role in lipid metabolism	Preclinical	Traditional	86
2	Antidiabetic agent	Peroxisome proliferator-activated receptor γ (PPAR γ)	Inhibits PPAR γ, which plays a role in lipid metabolism	Preclinical	Traditional	86
3	Antidiabetic agent	SGLT-2	Inhibits SGLT-2 and reduces blood glucose	Preclinical	Traditional	87
4	Antidiabetic agent	Aldose reductase (ALR2) inhibitor	Reduced glucose to sorbitol	Preclinical	Traditional	88
5	Antidiabetic agent	Glucagon binding to the glucagon receptor (GCGR)	GCGR is used to maintain blood glucose	Preclinical	Traditional	89
6	Antidiabetic agent	Glucagon binding to the glucagon receptor (GCGR)	GCGR is used to maintain blood glucose	Preclinical	Traditional	89
7	Antidiabetic agent	α-Glucosidase and amylase inhibition	Enzyme responsible for breaking down carbohydrates	Preclinical	Traditional	90
8	Antidiabetic agent	α-Glucosidase inhibition	Enzyme responsible for breaking down carbohydrates	Preclinical	Traditional	91