Compilation of ongoing research on thiophene derivatives for the development of anticancer agents.

Compound code	Indication	Cell lines/enzymes	Outcome	Status	Ref.
9	Antitumor activity	Inhibition of SF-268, MCF-7 and H460 cell lines	Prevent the proliferation and growth of tumor	Preclinical	94
10	Anticancer agent	Inhibition of H460 and MCF-7 cell lines	Prevent the proliferation and growth of tumor	Preclinical
11	Ant-proliferative activity	Inhibition of MCF-7 cell line	Inhibits the proliferation and growth of tumor	Preclinical
12	Antitumor activity	Inhibition of MCF-7 cell line	Prevent the proliferation and growth of tumor	Preclinical	95
13	Anticancer agent	Inhibition of human negroid cervix epitheloid carcinoma cells (HeLa)	Inhibits the proliferation and growth of tumor	Preclinical	96
14	Antitumor activity	HepG2 cell line	Inhibits the proliferation and growth of tumor	Preclinical	97
15	Anticancer agent	MCF-7	Inhibits the proliferation and growth of tumor	Preclinical	98
16	Antitumor activity	Colon cell line (HCT-116), glioblastoma cancer cell line (SF-295), leukaemia cell line (HL-60) and human ovary cell line (OVCAR-8)	Prevent the proliferation and growth of tumor	Preclinical	99
17	Anticancer agent	MCF-7	Inhibits the proliferation and growth of tumor	Preclinical	100
18	Anticancer agent	Protein tyrosine phosphate B (PTP1B)	Inhibits the proliferation and growth of tumor	Preclinical	76
19	Antitumor activity	Cell lines like T-lymphoma CEM and Molt/4, kidney Caki-1, prostate PC-3, and hepatoma Huh-7 tumour cells	Prevent the proliferation and growth of tumor	Preclinical	101
20	Antitumor activity	Hepatocellular panel of cell lines. Compound 20 showed potent activity against HEPG-2	Prevent the proliferation and growth of tumor	Preclinical	102
21	Antitumor activity	HepG-2 and A-549 cell lines	Prevent the proliferation and growth of tumor	Preclinical	103
22	Antitumor activity	EGFR-TK and Topo II	Prevent the proliferation and growth of tumor	Preclinical	104
23	Antitumor activity	Lung cancer cell line	Inhibits the proliferation and growth of tumor	Preclinical	112
24	Anticancer agent	HeLa, HepG2, CFPAC-1, SW620, and A549	Prevent the proliferation and growth of tumor	Preclinical	106
25	Anticancer agent	VEGFR-2, PDGFR, Pim-1 kinase	Prevent the proliferation and growth of tumor	Preclinical	107
26	Anticancer agent	Inhibition of HUVEC and HCT116 cell lines	Prevent the proliferation and growth of tumor	Preclinical	108
27	Anticancer agent	Inhibition of MCF-7 cell line	Prevent the proliferation and growth of tumor	Preclinical	109
28	Anticancer agent (MCF-7, PanC-1 and HepG2)	Inhibition of VEGFR-2 and EGFR	Inhibits the proliferation and growth of tumor	Preclinical	110
29	Anticancer agent (human pancreatic cell line)	Inhibition of EGFR2 enzyme	Prevent the proliferation and growth of tumor	Preclinical	111