Compilation of ongoing research on thiophene derivatives for the development of CNS disorder inhibitors.

Compound code	Indication	Biological target	Mechanism	Status	Ref.
30	Neurodegenerative agent	Catechol-O-methyltransferase (COMT)	Reduce the action of dopamine	Preclinical	113
31	Alzheimer disease	Acetylcholinesterase (AChE) enzyme	Block the dopamine	Preclinical	114
32	Neurodegenerative agent	Acetylcholinesterase (AChE) enzyme	Reduce the action of dopamine	Preclinical	115
33	Neurodegenerative agent	Beta-secretase activity (BACE1).	Block the dopamine	Preclinical	120
34	Neurodegenerative agent	Carbonic anhydrase I and II (hCA I and II) and acetylcholinesterase (AChE) enzyme	Reduce the action of dopamine	Preclinical	117
35	Parkinson's disease	Monoamine oxidase B (MAO-B) inhibitors	Block the dopamine	Preclinical	118
36	Neurodegenerative agent	Butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE)	Reduce the action of dopamine	Preclinical	119