Compilation of ongoing research on thiophene derivatives for the development of anti-inflammatory agents.

Compound code	Indication	Biological target	Mechanism	Status	Ref.
37	Anti-inflammatory agent	Inhibiting the pro-inflammatory agents such as ERK, THP-1 and NF-κB	Reduce the inflammatory mediators	Preclinical	129
38	Anti-inflammatory (anticancer)	Inhibition of 5-lipoxygenase enzyme	Decrease the production of leukotrienes	Preclinical	121
39	Anti-inflammatory agent (asthma)	Inhibition of 5-lipoxygenase enzyme	Decrease the production of leukotrienes	Preclinical	122
40	Anti-inflammatory agent	LOX	Decrease the production of leukotrienes	Preclinical
41	Anti-inflammatory agent	LOX	Decrease the production of leukotrienes	Preclinical	123
42	Anti-inflammatory agent	COX-2/5-LOX dual inhibitors	Decrease the production of leukotrienes	Preclinical	124
43	Anti-inflammatory agent	LOX	Decrease the production of leukotrienes	Preclinical	125
44	Anti-inflammatory agent	CXCR4 receptor	Decrease the production of leukotrienes	Preclinical	74
45	Anti-inflammatory agent	5-LOX inhibitors	Reduce the inflammatory mediators	Preclinical	127
46	Anti-inflammatory agent	COX-2 inhibitors	Decrease the production of leukotrienes	Preclinical	37
47	Anti-inflammatory agent	COX-2 inhibitors	Decrease the production of leukotrienes	Preclinical	128