Table 2: Factors and Conditions Associated with Increased Risk for Acute Coronary Events.

Coronary Plaque Characteristics	Coronary Blood Flow Dynamics	Intrinsic Hemostasis Factors	Metabolic and Inflammatory Conditions	Neurohormonal Imbalance	Environmental Factors and Drugs
Plaque burden	Blood viscosity	Platelet function/volume	Diabetes	Stress	Smoking
Lumen encroachment	Shear stress	Circadian variation	Obesity	Catecholamine surges	Pollution
Lesion location	Reduced blood flow/low cardiac output	Factor V Leiden deficiency	Dyslipidemia	Depression	Climate
Plaque composition	Vascular tone and reactivity	Von Willebrand factor deficiency	Connective tissue diseases	Exertion	Legal drugs
Plaque biology	Arterial hypertension	Anti-phospholipid syndrome	Infections	Autonomic dysfunction	Illegal drugs
Plaque configuration and remodeling			Renal disease	Endocrine imbalance	Diet
Endothelial dysfunction					Sedentary lifestyle

Source: Arbab-Zadeh et al.[94] Reproduced with permission from Wolters Kluwer Health.