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. 2024 Nov 7;18(11):e0012612. doi: 10.1371/journal.pntd.0012612

Fig 4. Treatment with CoPP prevents QTc prolongation and improves cardiac mechanical function at later times.

Fig 4

BALB/c mice were infected with 50 blood trypomastigotes of the T. cruzi Y strain and treated daily with CoPP (5 mg/Kg, i.p.) in the period 0–8 dpi, then assessed at the chronic period of infection, from 60–150 dpi. (A) Parasitemia (n = 6–15 mice per group), (B) Survival (n = 6-15mice per group), (C-G) EKG parameters (n = 5–12 mice per group): heart rate (RR interval); duration of PR interval; duration of P wave; duration of QRS; QT interval corrected by heart rate. (H-K) Echo parameters (n-5-9 mice per group): % Ejection Fraction (stroke volume/ end diastolic volume); Stroke volume (μL); Left Ventricle area and Right Ventricle area, mm2, transverse section. NI = not infected;— = infected and untreated mice; CoPP = infected mice treated with CoPP.