Table 1. Demographic and clinical characteristics of women and their newborns.
| Variable | MATERNAL GROUPS (N=185) | P value | ||
|---|---|---|---|---|
| PPROM (+) AF infection n=61 | PPROM (−) AF infection n=62 | PPROM No Amniocentesis n=62 | ||
| Maternal characteristics at enrollment and hospital course | ||||
| Age, years ‡ | 30 [25–35] | 29 [24–33] | 31 [23–36] | 0.791 |
| Gravidity ‡ | 3 [1–5] | 2 [1–3] | 3 [2–4] | 0.396 |
| Parity ‡ | 1 [0–2] | 0 [0–1] | 1 [0–2] | 0.239 |
| Race § Caucasian African-American Hispanic Other |
21 (34) 26 (43) 11 (18) 3 (5) |
34 (55) 13 (21) 8 (13) 7 (11) |
27 (44) 18 (29) 15 (24) 2 (3) |
0.039 |
| Body Mass Index ‡ | 27 [24–34] | 27 [25–33] | 31 [25–36] | 0.216 |
| Gestational age, weeks ‡ | 27.3 [24.8–30.1] | 31.3 [29.4–32.4] | 30.8 [25.6–33.1] | <0.001 |
| Uterine contractions § | 15 (25) | 16 (26) | 26 (42) | 0.066 |
| Clinical chorioamnionitis § | 9 (15) | 3 (5) | 4 (6) | 0.111 |
| History of preterm birth § | 16 (26) | 15 (24) | 11 (18) | 0.501 |
| Cervical dilatation >2cm § | 16 (26) | 10 (16) | 3 (5) | 0.006 |
| Steroid exposure during pregnancy § | 60 (98) | 54 (87) | 52 (84) | 0.021 |
| Prenatal antibiotic treatment § | 55 (90) | 58 (94) | 57 (92) | 0.789 |
| Antenatal magnesium sulfate § | 10 (16) | 17 (27) | 11 (18) | 0.254 |
| Outcome characteristics | ||||
| PPROM-to-delivery (latency), hours ‡ | 30 (18–114) | 91 (27–284) | 93 (22–271) | 0.006 |
| Amniocentesis-to-delivery, hours ‡ | 12 [5–22] | 60 [20–192] | NA | <0.001 |
| Delivery within 72 hours from rupture § | 55 (90) | 32 (52) | NA | <0.001 |
| Gestational age at delivery, weeks † | 27.4 [25.2–30.8] | 32.2 [30.1–33.4] | 31.9 [27.3–33.6] | <0.001 |
| Birthweight, grams ‡ | 990 [780–1535] | 1848 [1451–2137] | 1755 [985–2146] | <0.001 |
| Cesarean delivery § | 30 (49) | 23 (37) | 31 (50) | 0.272 |
| Apgar score at 1 minute ‡ | 7 [3–8] | 8 [6–9] | 8 [5–9] | 0.038 |
| Apgar score at 5 minutes ‡ | 8 [6–9] | 9 [8–9] | 9 [8–9] | 0.009 |
‡
Data presented as median [interquartile range] and analyzed by Kruskal-Wallis ANOVA;
§
Data presented as n (%) and analyzed by Chi square tests;
P values in bold font are considered significant based on P<0.05.
Abbreviations: PPROM, preterm premature rupture of membranes; IAI, intra-amniotic inflammation