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Medicinal chemistry associated with 81 (LQZ-7). (A, B) Chemical structures of the hit compound 81 and its six analogs including 7 and its hydrolysis product 8. (C) Chemical structures of 87 (LQZ-7G), 88 (LQZ-7H), 9 (LQZ-7I), 89 (LQZ-7J), and 90 (LQZ-7K) originated from 81. Labile hydrazone linker and other linkers are highlighted in cyan. 7 has a fused tetracyclic ring. 9 differs from other analogs 87–90 mainly by the substitution patterns on the two benzene rings.
