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Medicinal chemistry associated with 97 (Abbott 8). (A-B) Chemical structures of the hit compound 96 (Abbott 1), (A) and its analog 97 (B). (C) Functional groups linked to the two benzene rings on 96. (D) Hydrophilic moieties that are used to modify ring I. (E) The leading compound 10 (LLP3) and its analog 98 (LLP9). (F) A series of novel fused tricyclic ring analogs. (G–H) Six series of 97 analogs with different substitutions. Bn, benzyl. Key structural differences were highlighted.
