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Medicinal chemistry of 2. (A) Chemical structures of 35 (NDGA) and 2. (B–E) Ether bond (B), ester bond (C), end-ring (D), and linear or cycled carbon chain bridge (E) modifications on compound 2. (F) Chemical structure of 36 (NDGA-Cl2). (G) Compound 2 analogs with different length of the carbon-bridge or number of hydroxyl groups on benzene rings.
