Table 1.
Members of the IAPs, and the Status of Reported Inhibitors
| gene name | protein name | year identified | molecular mass (kDa) | inhibitorsa | development stage |
|---|---|---|---|---|---|
| BIRC1 | NAIP | 1995 | 160 | none reported | |
| BIRC2 | cIAP1 | 1995 | 69 | SM-1295 | Preclinical7 |
| AZD5582 | Preclinical8 | ||||
| AT-406 | Phase I9 | ||||
| ASTX660 | Phase I/II10 | ||||
| Birinapant | Phase I/II11 | ||||
| BIRC3 | cIAP2 | 1995 | 68 | SM-1295 | Preclinical7 |
| AZD5582 | Preclinical8 | ||||
| AT-406 | Phase I9 | ||||
| LCL161 | Phase I12 | ||||
| BIRC4 | XIAP | 1996 | 55 | MX69 | Preclinical13 |
| AZD5582 | Preclinical8 | ||||
| GDC-0152 | Phase I14 | ||||
| LCL161 | Phase I12 | ||||
| ASTX660 | Phase I/II10 | ||||
| BIRC5 | Survivin | 1997 | 16.5 | YM155 | Phase II15 |
| EM-1421 | Phase I16 | ||||
| FL118 | INDb,17 | ||||
| UC-112/MX106 | Preclinical18 | ||||
| LQZ-7F/7F1/7I | Preclinical19–21 | ||||
| BIRC6 | BRUCE | 1998 | 528 | None reported | |
| BIRC7 | ML-IAP or Livin | 2000 | 33 | None reported | |
| BIRC8 | ILP2 | 2001 | 27 | None reported |
a
Small molecule agents.
b
IND, investigational new drug.