. Author manuscript; available in PMC: 2024 Nov 25.

Published in final edited form as: J Med Chem. 2023 Dec 13;66(24):16515–16545. doi: 10.1021/acs.jmedchem.3c01130

Table 3.

Pharmacokinetic Profiles of Compounds 1, 2 and 3

compounds	species	route	T_max^a(h)	T_1/2(h)	C_max(ng/mL)	Cl(mL/h/kg)	AUC (ng × h/mL)	F (%)
1 (YM155)	human⁹²	IV	ND	26.3	10.7	47 700	1439	ND
	human⁶¹	IV	45.98	17.18	11.95	34 030	1832	ND
2 (EM-1421)	mouse⁹⁵	IV	0.08	ND	1064.60	ND	2984.54	ND
	mouse⁹⁵	Oral	8.0	ND	441.51	ND	2635.47	88.29
	human¹⁶	IV	ND	17.1	ND	54 000	ND	ND
3 (FL118)	mouse⁸¹	IV	0.17	1.8	43	14 287	82	ND

Abbreviations used: T_max, the time it takes for a drug to reach the maximum concentration. T_1/2, the time required for plasma concentration of a drug to decrease by 50%. C_max, the maximum concentration in plasma. Cl, clearance rate. AUC, the aera under the curve. F, fraction absorbed (bioavailability). ND, not determined. IV, intravenously.