. Author manuscript; available in PMC: 2024 Nov 25.

Published in final edited form as: J Med Chem. 2023 Dec 13;66(24):16515–16545. doi: 10.1021/acs.jmedchem.3c01130

Table 9.

SARs Associated with Compounds 81 and 9^a

position/scaffold	SAR

	Benzene rings a and b are tolerant of modification with hydrophobic substituents, such as methyl, nitro, halogen or carboxylate ester; Other fused ring structures in a are less favorable.²⁰
	The hydrazone linker is unstable and may undergo hydrolysis under acidic conditions;²¹ Its replacement with a secondary amine bond is generally favorable.¹⁹
	The motif of phenylfuran is tolerable to be replaced.²⁰
	Two fluorine substituents are favorable for cytotoxicity; Their replacement with electropositive substituent may decrease cytotoxicity;¹⁹
	The NHs is necessary to form hydrogen bonds with residues in the survivin dimeric interface; Its replacement with OH is less favorable.¹⁹

The highlighted elements are the points of discussion.