Fig. 1. TP53 inactivation and ERG overexpression promote the growth of immature erythroid progenitors.

A Experimental scheme used in (B–D). Human cord blood (CB) CD34⁺ cells were transduced with p53DD (coexpressing NGFR) and ERG (coexpressing GFP) and cultured in the presence of EPO. B Proliferation curves of CB cells transduced with vector, p53DD, ERG, or p53DD+ERG for 4 days. Results are expressed as mean ± s.e.m. of three independent experiments. ^****P < 0.0001. CD71 and CD235a expression (C) and Wright-Giemsa-staining (D), original magnification x400) of CB cells transduced with vector, p53DD, ERG, or p53DD+ERG. E CD235a expression of F36P, HEL, and TF-1 cells transduced with vector or ERG.