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. 2024 Sep 15;38(12):2614–2627. doi: 10.1038/s41375-024-02394-5

Fig. 1. TP53 inactivation and ERG overexpression promote the growth of immature erythroid progenitors.

Fig. 1

A Experimental scheme used in (B–D). Human cord blood (CB) CD34+ cells were transduced with p53DD (coexpressing NGFR) and ERG (coexpressing GFP) and cultured in the presence of EPO. B Proliferation curves of CB cells transduced with vector, p53DD, ERG, or p53DD+ERG for 4 days. Results are expressed as mean ± s.e.m. of three independent experiments. ****P < 0.0001. CD71 and CD235a expression (C) and Wright-Giemsa-staining (D), original magnification x400) of CB cells transduced with vector, p53DD, ERG, or p53DD+ERG. E CD235a expression of F36P, HEL, and TF-1 cells transduced with vector or ERG.