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. 2024 Nov 8;25(12):2297–2307. doi: 10.1038/s41590-024-01999-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a) Representative flow cytometry plot of PD1 and Tim3 expression on CD8⁺ T cells in day 14 B16 tumors and dLNs. b) Volcano plot of differentially expressed genes in progenitor vs terminally exhausted T cells. c) Representative histogram and quantification of Slamf6 expression in B16 dLN CD8⁺ T cells, and B16 tumor infiltrating T_pex and T_ex (n = 8 for all groups). d) Representative histogram and quantification of Tox expression in B16 dLN CD8⁺ T cells (n = 4), and B16 tumor infiltrating T_pex (n = 4) and T_ex cells (n = 4). e) Representative histogram and quantification of CD147 expression in dLN CD8⁺ (n = 3), and B16 tumor infiltrating T_pex (n = 9) and T_ex cells (n = 9). f) Representative histogram and quantification of hypoxyprobe staining in B16 dLN CD8⁺ T cells (n = 3), and B16 tumor infiltrating T_pex (n = 3) and T_ex cells (n = 3). g) Expression of SLC16A11 from single cell analysis in human effector and T_ex cells in various human tumors. Data represent one (d,f) or two (c,e) independent experiments. Error bars indicate +/− standard error of mean (SEM). Statistical analysis performed by one way analysis of variance (ANOVA) with Tukey’s multiple comparisons test (c-f).

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