Table 1.
Characteristics of 52 important proteins and biological function pathways.
| Gene name | Protein name | p-value | FC | % (Naïve) | % (Positive) | Expression |
|---|---|---|---|---|---|---|
| Apoptosis signaling pathway | ||||||
| DFFB | DNA fragmentation factor subunit beta | 0.018 | 0.95 | 100 | 100 | Down |
| HNRNPU | Heterogeneous nuclear ribonucleoprotein U isoform b | 0.019 | 0 | 81.48 | 40 | Down |
| MYBL2 | MYB proto-oncogene like 2 | 0.014 | 16.42 | 18.52 | 80 | UP |
| NGDN | Neuroguidin isoform 2 | 0.03 | 1.05 | 74.07 | 100 | UP |
| NME6 | Nucleoside diphosphate kinase | 0.029 | 16.76 | 14.81 | 60 | UP |
| Viral activities | ||||||
| CDYL2 | Chromo domain-containing protein | 0.035 | 0 | 55.56 | 0 | Down |
| CGNL1 | Cingulin like 1 | 0.035 | 0 | 70.37 | 20 | Down |
| DDX11 | Helicase ATP-binding domain–containing protein | 0.026 | 0 | 59.26 | 0 | Down |
| ERCC2 | General transcription and DNA repair factor IIH helicase subunit XPD | 0.037 | 0 | 77.78 | 20 | Down |
| GOLGB1 | Golgin B1 | 0.007 | 0 | 92.59 | 40 | Down |
| NCAPH | Condensin complex subunit 2 | 0.042 | 0 | 62.96 | 20 | Down |
| NSA2 | Ribosome biogenesis protein NSA2 homolog | 0.014 | 0 | 74.07 | 20 | Down |
| PAPOLA | Poly(A) polymerase | 0.045 | 0 | 51.85 | 0 | Down |
| ERCC6L | ERCC excision repair 6 like, spindle assembly checkpoint helicase | 0.026 | 1.12 | 51.85 | 100 | UP |
| POLA2 | DNA polymerase alpha subunit B | 0.018 | 1.13 | 55.56 | 100 | UP |
| POLH | DNA polymerase eta | 0.033 | 15.51 | 40.74 | 100 | UP |
| Neurological damage | ||||||
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2 | 0.042 | 0 | 62.96 | 20 | Down |
| CAPN6 | Calpain-6 (Fragment) | 0.02 | 0 | 77.78 | 40 | Down |
| EDC3 | Enhancer of mRNA-decapping protein 3 | 0.02 | 0 | 0 | 20 | Down |
| EDNRB | Endothelin receptor type B | 0.016 | 0 | 3.7 | 40 | Down |
| HTR1A | 5-Hydroxytryptamine receptor 1A | 0.045 | 0 | 51.85 | 0 | Down |
| ITGA7 | Integrin subunit alpha 7 | 0.042 | 0 | 62.96 | 20 | Down |
| MCF2L | MCF.2 cell line–derived transforming sequence like | 0.045 | 0 | 51.85 | 0 | Down |
| PCYT2 | Ethanolamine-phosphate cytidylyltransferase isoform 2 | 0.025 | 0 | 81.48 | 40 | Down |
| RALGAPA1 | Rap-GAP domain-containing protein | 0.018 | 0.94 | 96.3 | 100 | Down |
| TNFAIP1 | TNF-alpha–induced protein 1 | 0.031 | 0 | 74.07 | 40 | Down |
| VAV2 | Vav guanine nucleotide exchange factor 2 | 0.045 | 0 | 51.85 | 0 | Down |
| RAB1A | RAB1A, member RAS onco family | 0.008 | 12.67 | 7.41 | 60 | UP |
| Immune and inflammatory responses | ||||||
| DDX3X | RNA helicase | 0.045 | 0.95 | 88.89 | 60 | Down |
| EPHA2 | Ephrin type-A receptor 2 | 0.031 | 0.96 | 92.59 | 60 | Down |
| FLII | FLII actin remodeling protein | 0.016 | 0.91 | 92.59 | 60 | Down |
| GCNT1 | Glucosaminyl (N-acetyl) transferase 1 | 0.013 | 0 | 85.19 | 40 | Down |
| NOS3 | Nitric oxide synthase | 0.045 | 0.92 | 81.48 | 60 | Down |
| RBBP6 | E3 ubiquitin-protein ligase RBBP6 | 0.01 | 0.92 | 92.59 | 80 | Down |
| ZC3H4 | Zinc finger CCCH-type containing 4 | 0.041 | 0 | 74.07 | 20 | Down |
| ZC3H6 | Zinc finger CCCH-type containing 6 | 0.015 | 0 | 66.67 | 0 | Down |
| ARHGAP26 | Rho GTPase–activating protein 26 | 0.01 | 1.07 | 92.59 | 100 | UP |
| CD36 | Platelet glycoprotein 4 | 0.001 | 16.93 | 11.11 | 80 | UP |
| CUL3 | Cullin-3 | 0.022 | 1.04 | 62.96 | 100 | UP |
| DUS1L | Dihydrouridine synthase 1 like | 0.004 | 1.13 | 66.67 | 100 | UP |
| FLT4 | Receptor protein-tyrosine kinase | 0.031 | 1.06 | 81.48 | 100 | UP |
| HCRT | Orexin (Hypocretin) | 0.018 | 1.24 | 81.48 | 100 | UP |
| HIF3A | Hypoxia-inducible factor 3 subunit alpha | 0.046 | 14.74 | 40.74 | 80 | UP |
| LRRFIP1 | Leucine-rich repeat flightless-interacting protein 1 isoform 5 | 0.036 | 1.09 | 100 | 100 | UP |
| LSM14A | LSM14A mRNA processing body assembly factor | 0.014 | 1.23 | 81.48 | 100 | UP |
| MUC5B | Mucin 5B, oligomeric mucus/gel-forming | 0.047 | 11.93 | 25.93 | 60 | UP |
| MYD88 | Myeloid differentiation primary response protein MyD88 | 0.035 | 1.06 | 88.89 | 100 | UP |
| Others | ||||||
| ADAMTS5 | Peptidase M12B domain-containing protein | 0.045 | 0 | 51.85 | 0 | Down |
| ADAMTSL1 | ADAMTS like 1 | 0.02 | 0 | 0 | 20 | Down |
| PI4KA | 1-Phosphatidylinositol 4-kinase | 0.02 | 1.09 | 70.37 | 100 | UP |
| ETNK2 | Ethanolamine kinase 2 | 0.02 | 1.27 | 55.56 | 100 | UP |
| OBSCN | Obscurin | 0.006 | 18.52 | 25.93 | 80 | UP |
% (Naïve) = (number of proteins detected in naïve samples/number in naïve samples) × 100; % (Positive) = (number of proteins detected in seropositive samples/number in seropositive samples) × 100 FoldChange (FC) = PELs (seropositive)/PELs (naïve).