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. 2024 Nov 12;15:1450064. doi: 10.3389/fgene.2024.1450064

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Copyright © 2024 Chen, Wang, Zou, Li, Yang, Su and Mo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spearman correlation heatmap showing associations between aging-associated bacterial genera and both upregulated (red-labeled) and downregulated (blue-labeled) metabolites in old mice. Differential genera, defined by the results from LEfSe and the intersection of LinDA and Welch’s t-test, were analyzed with Bonferroni correction to identify robust correlations. Significant correlations are indicated by *P < 0.05, **P < 0.01, and ***P < 0.001, with color intensity reflecting correlation strength.