The antiviral activity of EB depends on virus input.
Cell cultures (2 × 105 cells/well) were switched to
serum-free DMEM and infected with 19 (○), 210 (●), or 5,700 PFU
(Δ) of hrR3 per well EB was present from 1 h before
through 1 h after infection. lacZ+ cells
were scored 8 h postinfection. All data points are means of
triplicate measurements with standard errors of the means. The insert
shows the dependence of IC50s (0.66, 1.2, and 11 μM,
respectively) on the virus inputs.