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. 2024 Oct 9;29(12):1825–1839. doi: 10.1007/s10147-024-02632-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pembrolizumab versus EXTREME in the A PD-L1 CPS ≥ 20, B PD-L1 CPS ≥ 1, and C total Japanese populations at long-term follow-up and pembrolizumab-chemotherapy versus EXTREME in the D PD-L1 CPS ≥ 20, E PD-L1 CPS ≥ 1, and F total Japanese populations. ^aFrom the product-limit (Kaplan–Meier) method for censored data. ^bOn the basis of a Cox proportional hazards regression model with the Efron method of tie handling with treatment as a covariate. CI confidence interval, CPS combined positive score, HR hazard ratio, OS overall survival, PD-L1 programmed cell death ligand 1

Fig. 1 — Pembrolizumab versus EXTREME in the A PD-L1 CPS ≥ 20, B PD-L1 CPS ≥ 1, and C total Japanese populations at long-term follow-up and pembrolizumab-chemotherapy versus EXTREME in the D PD-L1 CPS ≥ 20, E PD-L1 CPS ≥ 1, and F total Japanese populations. ^aFrom the product-limit (Kaplan–Meier) method for censored data. ^bOn the basis of a Cox proportional hazards regression model with the Efron method of tie handling with treatment as a covariate. CI confidence interval, CPS combined positive score, HR hazard ratio, OS overall survival, PD-L1 programmed cell death ligand 1