TABLE 1. Anti-hypertensive Drugs to Treat Gestational Hypertension or Pre-eclampsia without Severe Features.^1,35.

	Agent	Dose	Recommendation	Side effects
First line	Labetalol (oral)	Initial dose: 100-200 mg twice a day Increase every 2-3 days Maximum dose 2,400 mg/day	Consider adding another low-dose medication if BP is not controlled with 200 mg, 3-4 times/day	Hypotension, increased liver enzyme levels, fetal bradycardia, neonatal hypoglycemia
	Extended release nifedipine (oral)	Initial dose: 30-60 mg every day Increase every 7-14 days Maximum dose 120 mg/day	Consider adding another low-dose medication if BP is not controlled with 60 mg/day	Risk of bronchospasm (avoid in asthma), severe headache, peripheral edema, anxiety, nightmares, dry mouth, hypotension. Contraindicated in aortic stenosis
	Alpha-methyldopa (oral)	Initial dose: 250 mg twice or three times a day Increase every two days Maximum dose 3,000 mg/day	Consider adding another low-dose medication if BP is not controlled with 500 mg, four times/day	Contraindicated in depression
Second or third line	Hydralazine	Initial dose: 10 mg four times a day Increase every 2-5 days Maximum dose 200 mg/day	Care should be taken when using because half of women experience associated side effects	Tachycardia (should never be used in isolation because of reflex tachycardia), headache, flushing, fetal distress, hypotension
	Hydrochlorothiazide	Initial dose: 12.5 mg every day Increase every 7-14 days Max. dose 200 mg/day	The use of thiazide diuretics can be associated with significant volume depletion within the first two weeks and intensive monitoring of volume status is recommended	Volume depletion, FGR, oligohydramnios

BP, blood pressure; FGR, fetal growth restriction.