Table 1.

Comparison of some sociodemographic and pharmacological variables according to the prescription of drugs that induce or inhibit cytochrome P450 in Colombia

Variables	Total		Inhibitors		Inductors		Inhibitors–inductors
	n = 63,433	%	n = 40,200	%	n = 22,689	%	n = 544	%
Woman	39,997	63.1	27,246	67.8	12,416	54.7	335	61.6
Age, median (interquartile range)	61.0 (44.0–73.0)		62.0 (43.0–74.0)		58.0 (44.0–70.0)		67.0 (54.5–77.0)
Origin
Caribbean region	27,747	43.7	16,094	40.0	11,392	50.2	291	48.0
Pacific region	12,357	19.5	8518	21.2	3692	16.3	147	27.0
Bogotá-Cundinamarca region	12,038	19.0	8376	20.8	3606	15.9	56	10.3
Central region	9430	14.9	5995	14.9	3365	14.8	70	12.9
Eastern region	1697	2.7	1097	2.7	590	2.6	10	1.8
Amazon region	164	0.3	120	0.3	44	0.2	0	0.0
Comorbidities
Arterial hypertension	28,430	44.8	19,876	49.4	8267	36.4	287	52.8
Diabetes mellitus	11,692	18.4	7092	17.6	4436	19.6	164	30.1
Hypothyroidism	7253	11.4	4881	12.1	2281	10.1	91	16.7
Epilepsy	6346	10.0	193	0.5	6098	26.9	55	10.1
Chronic kidney disease	2624	4.1	1982	4.9	603	2.7	39	7.2
Number of drugs per patient, median (interquartile range)	5.0 (3.0–8.0)		5.0 (3.0–7.0)		5.0 (2.0–8.0)		9.0 (6.0–11.0)
No polypharmacy	28,353	44.7	17,399	43.3	10,894	48.0	60	11.0
Polypharmacy	26,002	41.0	17,861	44.4	7877	34.7	264	48.5
Excessive polypharmacy	8743	13.8	4796	11.9	3743	16.5	204	37.5
Extreme polypharmacy	335	0.5	144	0.4	175	0.8	16	2.9
Comedications	55,562	87.6	35,485	88.3	19,547	86.2	530	97.4
Antihypertensives and diuretics	30,384	47.9	21,074	52.4	8932	39.4	378	69.5
Lipid-lowering	24,444	38.5	16,582	41.2	7554	33.3	308	56.6
Analgesics and anti-inflammatories	21,120	33.3	12,624	31.4	8223	36.2	273	50.2
Anti-ulcer	17,915	28.2	11,198	27.9	6481	28.6	236	43.4
Micronutrients	13,509	21.3	7859	19.5	5452	24.0	198	36.4
Pharmacokinetic interactions	19,086	30.1	11,420	28.4	7164	31.6	502	92.3
Major	18,679	29.4	11,016	27.4	7162	31.6	501	92.1
Contraindicated	821	1.3	794	2.0	3	0.0	24	4.4