Table 4.

Binary logistic regression on the variables related to the presence of contraindicated or major pharmacological interactions among users of inhibitors and inducers of cytochrome P450 in Colombia

Variables	cOR	95% CI		p-Value	aOR	95% CI		p-Value
		Lower	Upper			Lower	Upper
Male (yes/no)	1.016	0.981	1.052	0.385	1.148	1.104	1.194	<0.001
Age ≥65 years	1.023	0.988	1.058	0.200	Ref.	Ref.	Ref.
Age 18–39 years	0.830	0.795	0.866	<0.001	1.778	1.670	1.894	<0.001
Age 40–64 years	1.107	1.069	1.146	<0.001	1.643	1.569	1.720	<0.001
Bogotá-Cundinamarca region (yes/no)	0.864	0.827	0.903	<0.001	0.999	0.952	1.049	0.964
Cardiovascular disorders (yes/no)	1.312	1.268	1.358	<0.001	0.975	0.932	1.020	0.269
Neurological disorders (yes/no)	1.181	1.131	1.233	<0.001	1.283	1.215	1.354	<0.001
Rheumatologic disorders (yes/no)	2.066	1.945	2.195	<0.001	1.324	1.235	1.419	<0.001
Psychiatric disorders (yes/no)	4.028	3.777	4.296	<0.001	3.847	3.583	4.131	<0.001
Medication quantity (continued)	1.233	1.227	1.240	<0.001	1.242a	1.234	1.251	<0.001
Cytochrome inhibitors (yes/no)	0.896	0.865	0.929	<0.001	1.079	1.033	1.128	0.001
Statins (co-medication) (yes/no)	1.641	1.585	1.699	<0.001	1.142	1.089	1.197	<0.001
Opioid and non-opioid analgesics (co-medication) (yes/no)	2.213	2.137	2.293	<0.001	1.331	1.277	1.388	<0.001
Antiparasitics (co-medication) (yes/no)	2.498	2.331	2.677	<0.001	2.883	2.667	3.117	<0.001

aOR adjusted odds ratio; CI confidence interval; cOR crude odds ratio; Ref. reference

^a24.2% higher risk for each drug, from two drugs