Table 2.

Multiple linear regression analyses of the (a) annual bleeding rate (ABR) and (b) annual joint bleeding rate (AjBR)

	Estimate	SE	p-Value
(a) Annual bleeding rate
Age (years)	0.05	0.07	0.528
Education (0 = high school or preschool, 1 = college or higher)	− 0.15	1.68	0.927
Blood type (0 = Non-O type, 1 = O type)	1.47	1.75	0.401
Body mass index (kg/m2)	0.68	1.69	0.688
Occupation (0 = employed or under-employed, 1 = student)	− 3.24	2.01	0.110
History of FVIII inhibitor (0 = FVIII inhibitor ≤ 0.6 BU, 1 = FVIII inhibitor > 0.6 BU)	4.76	1.57	0.003**
Follow-up year (1 = 1st follow-up year, 2, 3, 4 = 2nd, 3rd, 4th follow-up year)	− 5.63	0.56	< 0.001**
R2	0.43
1st year of prophylactic treatment	− 20.94	2.55	< 0.001**
2nd year of prophylactic treatment	− 23.29	2.60	< 0.001**
3rd year of prophylactic treatment	− 24.47	2.67	< 0.001**
4th year of prophylactic treatment	− 25.41	2.87	< 0.001**
(b) Annual joint bleeding rate
Age (years)	0.10	0.05	0.076
Education (0 = high school or preschool, 1 = college or higher)	0.36	1.25	0.776
Blood type (0 = Non-O type 1 = O type)	1.25	1.30	0.339
Body mass index (kg/m2)	0.22	1.25	0.864
Occupation (0 = employed or under-employed, 1 = student)	− 1.79	1.50	0.235
History of FVIII inhibitor (0 = FVIII inhibitor ≤ 0.6 BU, 1 = FVIII inhibitor > 0.6 BU)	3.53	1.17	0.003**
Follow-up year (1 = 1st follow-up year, 2, 3 ,4 = 2nd, 3rd, 4th follow-up year)	− 3.71	0.42	< 0.001**
R2	0.38
1st year of prophylactic treatment	− 12.97	2.14	< 0.001**
2nd year of prophylactic treatment	− 15.01	2.10	< 0.001**
3rd year of prophylactic treatment	− 15.67	2.19	< 0.001**
4th year of prophylactic treatment	− 16.31	2.34	< 0.001**

BU Bethesda unit, FVIII factor VIII, SE standard error

**p < 0.005