Table 3.

Clinical significance of the Hemophilia Activities List (HAL) and Hemophilia Joint Health Score (HJHS) in patients with severe hemophilia A before and after prophylaxis, and quality of life (QoL) in patients with severe hemophilia A before and after prophylaxis, from a single institution

	Before prophylaxis	After prophylaxis	p-value
Hemophilia Activities List (HAL), mean (SE)
Age > 18 years (n = 27)	78.06 (4.39)	79.59 (3.93)	0.735
Age ≤ 18 years (n = 6)	79.82 (4.75)	98.57 (0.55)	0.021*
Hemophilia Joint Health Score (HJHS)
Age > 18 years (n = 27)	37.15 (4.12)	33.27 (4.13)	0.681
Age ≤ 18 years (n = 6)	5.40 (1.99)	5.00 (0.11)	0.410
Quality of life (QoL)
A single institution (n = 18)	38.88 (3.64)	23.24 (2.45)	0.036*

* p < 0.05